• Kuangyi Li, Shilan Li, Jiana Hong, Weiyin Cheng, Yingjian Zhang, Zhangrong Liang, Qi Tang, and Bisheng Shen.
• Department of Emergency Medicine, Foshan Hospital of Traditional Chinese Medicine, Foshan City, Guangdong Province, China.
• Medicine (Baltimore). 2023 Oct 27; 102 (43): e35780e35780.

RationaleStreptococcus suis (S suis)-associated infections are uncommon but life-threatening diseases. The clinical manifestations vary from general symptoms of bacterial infection to fatal meningitis. The clinical manifestation and routine diagnostic testing is not specific enough to obtain well-time diagnosis.Patient Concerns And DiagnosisWe report a case of meningitis and sepsis caused by S suis infection. A 70-year-old woman presented to our emergency department with generalized pain. After hospital admission, her condition rapidly deteriorated to fever, intracranial hypertension, and disturbance of consciousness. Examination of the blood and cerebrospinal fluid with metagenomic next-generation sequencing and bacterial cultures revealed S suis infection.Interventions And OutcomesAfter anti-infection therapy with meropenem and vancomycin, the patient recovered and was discharged from the hospital with no residual effects.LessonsHuman infections with S suis are extremely rare. If clinicians encounter a patient with fever, disturbance of consciousness, and intracranial hypertension, especially those who have been exposed to raw pork, S suis infection should be considered. Metagenomic next-generation sequencing can be a useful adjunct for the rapid diagnosis of S suis infection and aid in the planning of clinical treatment. Meanwhile, public health awareness is necessary to limit the risk of S suis infection.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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