• Medicine · Nov 2023

    Meta Analysis

    Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis.

    • Mathias Orellana-Donoso, Michelle López-Chaparro, Marisol Barahona-Vásquez, Andrés Santana-Machuca, Alejandro Bruna-Mejias, Pablo Nova-Baeza, and Juan José Valenzuela-Fuenzalida.
    • Escuela de Medicina, Universidad Finis Terrae, Santiago, Chile Departamento de Morfología, Facultad de Medicina.
    • Medicine (Baltimore). 2023 Nov 3; 102 (44): e35368e35368.

    BackgroundThis systematic review explores the most current evidence regarding the mechanisms of neuropathic pain in patients with different types of diabetes and how this pain affects different functional and structural components of the neuroanatomical pain pathways. The review also seeks to provide guidelines for the best approach and treatment for patients experiencing this type of pain. The objective is to determine the effectiveness of alpha-lipoic acid (ALA) in improving functional and symptomatic outcomes in patients with diabetes mellitus type I and type II.ObjectiveTo determine the effectiveness of alpha-lipoic acid (ALA) in improving functional and symptomatic outcomes in patients with diabetes mellitus type I and type II.MethodsWe systematically search MEDLINE (via PubMed), EMBASE, SCOPUS, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature, and Web of Science databases.ResultsThe findings of this review show that different forms of ALA do not present statistically significant changes for any of the scales included, including total symptom score (standardized mean difference [SMD] = -3.59, confidence interval [CI] = -4.16 to -3.02, and P < .00001), neuropathy impairment score (SMD = -1.42, CI = -3.68 to 0.84, and P = .22), and neuropathy symptom checklist (SMD = -0.09, CI = -0.15 to -0.02, and P = .01).ConclusionIn comparison to the use of a placebo, the findings suggest that ALA does not exhibit significant differences in terms of pain reduction and different functional scales. Moreover, no specific dosages are identified to support the use of ALA for the reduction of neuropathic pain.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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