• Preventive medicine · May 2011

    Randomized Controlled Trial

    Effects of 12-month exercise on health-related quality of life: a randomized controlled trial.

    • Ikuyo Imayama, Catherine M Alfano, Lisa A Cadmus Bertram, Chiachi Wang, Liren Xiao, Catherine Duggan, Kristin L Campbell, Karen E Foster-Schubert, and Anne McTiernan.
    • Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA. iimayama@fhcrc.org
    • Prev Med. 2011 May 1; 52 (5): 344351344-51.

    ObjectiveWe investigated exercise effects on health-related quality of life (HRQOL) and exercise self-efficacy, and tested effect modification by baseline body mass index (BMI) and gender.MethodsMiddle-aged women (n=100) and men (n=102) were randomly assigned to either exercise (360 min/week of moderate-to-vigorous aerobic exercise) or control in Seattle, WA, from 2001 to 2004. Demographics, anthropometrics, exercise self-efficacy (5-item self-efficacy questionnaire) and HRQOL (SF-36) were assessed at baseline and 12 months. Analysis of covariance adjusting for baseline scores was used to compare HRQOL and exercise self-efficacy scores between the exercise and control groups.ResultsAt 12 months, exercisers demonstrated higher exercise self-efficacy than controls (percent change from baseline: -6.5% vs. -15.0%, p < 0.01), without differences in HRQOL. Baseline BMI category and gender did not modify these effects. In exploratory analyses comparing exercisers and controls within subgroups defined by gender and BMI, 12-month HRQOL scores [role-physical (+7.0% vs. -13.1%), vitality (+15.6% vs. -4.2%), social functioning (+10.0% vs. -3.5%), and mental health (+6.8% vs. -2.9%)] were higher only among overweight male exercisers (p < 0.05, vs. control).ConclusionThree hundred and sixty minutes per week of exercise, recommended for weight maintenance, did not have negative effects on exercise self-efficacy or HRQOL. This level of exercise may increase HRQOL among overweight men.Copyright © 2011 Elsevier Inc. All rights reserved.

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