• Haidi Fan, Yanqiu Liu, Xin Zhang, Jian Sun, and Ning Lin.
• From the Department of Clinical Laboratory (Fan, Liu, Sun), Branch Hospital of Huai'an First People's Hospital; from the Department of Otolaryngology (Zhang); and from the Department of Clinical Laboratory (Lin), the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Jiangsu, China.
• Saudi Med J. 2023 Nov 1; 44 (11): 111311191113-1119.

ObjectivesTo assess the serum concentrations of soluble T-cell immunoglobulin and mucin domain 1 (sTIM-1) and soluble P-selectin (sP-selectin) in individuals who had obstructive sleep apnea-hypopnea syndrome (OSAHS).MethodsBetween December 2020 and November 2022, 134 participants from the Sleep Monitoring Center of the Branch Hospital of Huai'an First People's Hospital, Jiangsu, China, engaged in this cross-sectional study. Participants were categorized as mild OSAHS (n=19), moderate OSAHS (n=22), severe OSAHS (n=57), and non-OSAHS (n=36) groups. Serum levels of sTIM-1, sP-selectin, and interleukin (IL)-6, as well as baseline clinical characteristics and polysomnography outcomes were assessed in each participant.ResultsCompared to the non-OSAHS group, sTIM-1 and sP-selectin levels were considerably elevated in people who had moderate or severe OSAHS (all p<0.05), but there were no notable changes between those who had mild OSAHS and non-OSAHS participants (p>0.05). The sTIM-1 and sP-selectin levels showed positive associations with the apnea-hypopnea index, body mass index (BMI), and IL-6 levels (all p<0.001). While elevated sTIM-1 was independently related to OSAHS (odds ratio [OR]=1.134, p=0.001), sP-selectin was not associated with OSAHS after adjusting for BMI (OR=1.013, p=0.467).ConclusionPeople with moderate or severe OSAHS had higher serum sTIM-1 and sP-selectin levels, and elevated sTIM-1 is an independently related factor for OSAHS.Copyright: © Saudi Medical Journal.

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