• Resuscitation · Dec 2023

    First Documented Rhythm and Clinical Outcome in Children Who Undergo Extracorporeal Cardiopulmonary Resuscitation for In-Hospital Cardiac Arrest: A Report from the American Heart Association Get With The Guidelines® - Resuscitation Registry (GWTG-R).

    • Tanya Perry, Adnan Bakar, Melania M Bembea, Joanna Fishbein, Todd Sweberg, and American Heart Association's Get With The Guidelines®-Resuscitation Investigators.
    • Department of Cardiology, Cincinnati Children's Hospital Medical Center, The Heart Institute, The University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: Tanya.Perry@cchmc.org.
    • Resuscitation. 2023 Dec 1; 193: 110040110040.

    IntroductionOutcomes of conventional cardiopulmonary resuscitation are improved when the initial rhythm is shockable (ventricular fibrillation or pulseless ventricular tachycardia). In children, the first documented rhythm is typically asystole or pulseless electrical activity. We evaluate the role the initial rhythm plays in outcomes for children undergoing extracorporeal cardiopulmonary resuscitation (ECPR) for in-hospital cardiac arrest.MethodsConsecutive patients < 18 years with in-hospital ECPR events ≥ 10 minutes reported to the American Heart Association Get With The Guidelines® - Resuscitation registry from 2014 to 2019 were included. Primary outcome was survival to hospital discharge. Logistic regression modeling was used to compute propensity score matching based on patient, cardiac arrest event and hospital characteristics; patients with initial shockable rhythm were matched to patients with initial non-shockable rhythm.ResultsThe final cohort included 466 patients, of which 82 (18%) had a shockable, and 384 (82%) had a non-shockable initial rhythm. After propensity score matching of 287 (62%) patients, there was no difference in survival to hospital discharge (risk ratio [RR] 1.2, 95% CI, 0.95-1.53, p = 0.13) or favorable neurologic outcome, defined as Pediatric Cerebral Performance Category (PCPC) of 1 or 2, or no decline from baseline (RR 1.28, 95% CI, 0.84-1.96, p = 0.25) between patients with and without shockable initial rhythm.ConclusionsIn children with in-hospital cardiac arrest undergoing ECPR, there was no significant difference in survival or favorable neurologic outcome between those with initial shockable rhythm compared to non-shockable rhythm. Further investigation to evaluate ECPR patient characteristics and outcomes is warranted to help guide eligibility and ECMO deployment practices.Copyright © 2023 Elsevier B.V. All rights reserved.

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