• Medicine · Nov 2023

    Interleukin-6 and the determinants of severe COVID-19: A retrospective cohort study.

    • Wael Hafez, Prashant Nasa, Ahmed Khairy, Mohan Jose, Mahmoud Abdelshakour, Sabah Ahmed, Fatema Abdulaal, Nivedita Nair, Mohammad Ahmad, Vanya Jalal Rashid, Youmna Ayman, Steffi John, Osman Fdl Alla, Reham Abu Shady, Ahmed Ali Mohamed, Rami Soliman, and Simon Nader.
    • Internal Medicine, NMC Royal Hospital, Khalifa City, Abu Dhabi, United Arab Emirates.
    • Medicine (Baltimore). 2023 Nov 10; 102 (45): e36037e36037.

    AbstractCytokines, notably interleukin-6 (IL-6), increase considerably in patients with severe corona virus disease 2019 (COVID-19). This vigorous immune response may cause end-organ failure or death; hence, measuring IL-6 in the context of patient characteristics may help predict outcomes and encourage early comprehensive therapy. This study investigated the association between serum IL-6 levels, COVID-19 severity, and demographic, clinical, and biochemical characteristics. COVID-19 inpatients in NMC hospitals were investigated between November 2020 and November 2021. Several patient variables related to serum IL-6 and COVID-19 severity have been examined. The study included 374 COVID-19 inpatients, 235 of whom had severe disease with a median age of 51. The elderly had an increased risk of severe COVID-19 (73.8%) compared with young adults (71%), with higher white blood cells, D-dimer, Lactate dehydrogenase, creatinine, ferritin, prothrombin time, Procalcitonin, and fibrinogen levels (P < .001). C-reactive protein, troponin, intensive care unit admission, disease severity score, and mortality were significantly associated with higher serum IL-6 levels (P = .05) in the univariate analysis, but this significance disappeared in the multivariate analysis. IL-6, along with other demographic and clinical variables affected COVID-19 severity. These characteristics may predict patients at risk of severe disease and assist in establishing early comprehensive disease outcome strategies. Large-scale clinical research is needed to emphasize IL-6 and COVID-19.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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