• Ga Won Jeon, So Yoon Ahn, Su Min Kim, Misun Yang, Se In Sung, Ji-Hee Sung, Soo-Young Oh, Cheong-Rae Roh, Suk-Joo Choi, and Yun Sil Chang.
• Department of Pediatrics, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.
• J. Korean Med. Sci. 2023 Nov 13; 38 (44): e350e350.

BackgroundThough antenatal magnesium sulfate (MgSO4) is widely used for fetal neuroprotection, suspicions about the long-term neuroprotection of antenatal MgSO4 have been raised.MethodsWe investigated short- and long-term outcomes of antenatal MgSO4 use for 468 infants weighing < 1,500 g with a gestational age of 24-31 weeks.ResultsShort-term morbidities and the risk of developmental delay, hearing loss, and cerebral palsy at a corrected age of 18-24 months and 3 years of age did not decrease in the MgSO4 group (infants who were exposed to MgSO4 for any purpose) or neuroprotection group (infants who were exposed to MgSO4 for fetal neuroprotection) compared with the control group (infants who were not exposed to MgSO4). The z-scores of weight, height, and head circumference did not increase in the MgSO4 group or neuroprotection group compared with the control group.ConclusionAntenatal MgSO4 including MgSO4 for neuroprotection did not have beneficial effects on long-term neurodevelopmental and growth outcomes.© 2023 The Korean Academy of Medical Sciences.

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