• Thanh Tat Nguyen, Dat Tat Nguyen, Tien Thi-Hong Vo, Oanh Tran-Hoang Dang, Bao Trung Nguyen, Dung Thi-Thuy Pham, Thuong Thi-Kim Nguyen, Yen Nguyen-Hoang Duong, Duong Hung Doan, Truc Huynh Nguyen, Lien Thi Ho, Phuc Hoang Nguyen, Dung Ngoc Phan, Tin Van Tran, Tuyet Kim Nguyen, Duc Cong Luong, Anh Thi-Mai Pham, Thuy Thi-Diem Dinh, Viet Chau Do, and Luan Thanh Vo.
• Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam.
• Medicine (Baltimore). 2023 Nov 17; 102 (46): e36054e36054.

AbstractDengue-associated complications, including dengue shock syndrome, severe respiratory distress, and pediatric acute liver failure (PALF), are associated with high mortality rates in patients with dengue. There is increasing prevalence of overweight and obesity among children worldwide. Obesity may activate inflammatory mediators, leading to increased capillary permeability and plasma leakage in patients with dengue. Several studies have shown a correlation between obesity and DSS, but did not include dengue fatality or PALF. Therefore, we hypothesized possible associations between obesity and critical dengue-associated clinical outcomes among PICU-admitted children with DSS, including dengue-related mortality, mechanical ventilation (MV) requirements, and dengue-associated PALF. The nutritional status of the participants was assessed using World Health Organization growth charts. A total of 858 participants with complete nutritional data were enrolled in this study. Obesity was significantly associated with risk of severe respiratory failure and MV support (odds ratio = 2.3, 95% CI: 1.31-4.06, P < .01); however, it was not associated with dengue-associated mortality or acute liver failure. Obese pediatric patients with DSS should be closely monitored for severe respiratory distress and the need for high-flow oxygenation support, particularly MV, soon after hospitalization.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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