• Fandong Li, Mengtao Wu, Peng Wu, and Dianjun Tang.
• Department of Vascular Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
• Medicine (Baltimore). 2023 Nov 17; 102 (46): e36011e36011.

RationaleKlipple-Trenaunary Syndrome (KTS) complicated by frequent cellulitis of lower extremity seriously affects a patient quality of life. The hemodynamic characteristics of the disease are still unclear. Direct skin incision or puncture to remove malformed veins at the lesion site carries the risk of non-healing of the surgical incision. Our aim is to explore initial management strategies based on the hemodynamic characteristics of this disease.Patient ConcernsA 29-year-old Manchu man was affected by KTS from childhood, characterized by an increase of the circumference and superficial varicose veins of the lower extremity. In the past 5 years, he suffered from frequent cellulitis in the left leg every 15 days or so.DiagnosesKTS complicated by frequent cellulitis of lower extremity.InterventionsThe clinical and hemodynamic characteristics of KTS were evaluated by Doppler ultrasonography (DUS) combined with CT venography (CTV), and foam sclerotherapy and postoperative elastic bandage compression were performed accordingly.OutcomesBased on evaluations, the reason for frequent cellulitis was the continuous increase of venous hypertension in the calf caused by the malformed superficial vein and its penetrating vein. After 3 operations, the patient had no recurrence of cellulitis of the leg. Follow-up for 1 year showed no recurrence of left leg cellulitis.LessonsThis report emphasizes that foam sclerotherapy can significantly improve the clinical symptoms of KTS, such as cellulitis, and provide a safe skin environment for the implementation of other surgical methods, based on the evaluation of the pathological characteristics of KTS by DUS combined with CTV.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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