• Laura Sarkisian, IsseYusuf AbdiYADepartment of Cardiology, The Heart Center, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: Yusuf.abdi.isse.01@regionh.dk., Oke Gerke, OblingLaust Emil RoelsgaardLERDepartment of Cardiology, The Heart Center, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: laust.emil.roelsgaard.obling.01@regionh.dk., Ramus Paulin Beske, Johannes Grand, Henrik Schmidt, HøjgaardHenrik FrederiksenHFOdense University Hospital, Department of Anesthesiology, J.B. Winsløws Vej 4, 5000 Odense C, Denmark. Electronic address: Henrik.Frederiksen.Hoejgaard@rsyd.dk., MeyerMartin Abild StengaardMASDepartment of Cardiology, The Heart Center, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: martin.abild.stengaard.meyer@regionh.dk., Britt Borregaard, Christian Hassager, Jesper Kjaergaard, and Jacob Eifer Møller.
• Research Unit of Cardiology, Department of Cardiology, Odense University Hospital, J.B. Winsløws Vej 4, 5000 Odense C, Denmark; OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark. Electronic address: Laura.Sarkisian2@rsyd.dk.
• Resuscitation. 2024 Feb 1; 195: 110059110059.

Background And AimBystander defibrillation is associated with increased survival with good neurological outcome after out-of-hospital cardiac arrest (OHCA). Dispatch of lay responders could increase defibrillation rates, however, survival with good neurological outcome in these remain unknown. The aim was to compare long-term survival with good neurological outcome in bystander versus lay responder defibrillated OHCAs.MethodsThis is a sub-study of the BOX trial, which included OHCA patients from two Danish tertiary cardiac intensive care units from March 2017 to December 2021. The main outcome was defined as 3-month survival with good neurological performance (Cerebral Performance Category of 1or 2, on a scale from 1 (good cerebral performance) to 5 (death or brain death)). For this study EMS witnessed OHCAs were excluded.ResultsOf the 715 patients, a lay responder arrived before EMS in 125 cases (16%). In total, 81 patients were defibrillated by a lay responder (11%), 69 patients by a bystander (10%) and 565 patients by the EMS staff (79%). The 3-month survival with good neurological outcome was 65% and 81% in the lay responder and bystander defibrillated groups, respectively (P = 0.03).ConclusionIn patients with OHCA, 3-month survival with good neurological outcome was higher in bystander defibrillated patients compared with lay responder defibrillated patients.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

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