• Medicine · Nov 2023

    Review

    Genomic profiling for non-small cell lung cancer: Clinical relevance in staging and prognosis.

    • Abhinav Bhattarai, Sangam Shah, Hashem Abu Serhan, Ranjit Sah, and Sanjit Sah.
    • Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
    • Medicine (Baltimore). 2023 Nov 24; 102 (47): e36003e36003.

    AbstractLung cancer is one of the most common cancers prevalent and around 80% of all cases are non-small cell lung cancer (NSCLC). Due to high recurrence rates, the mortality of NSCLC is high. Conventional staging systems allowed risk classification of patients in order to simplify the patient selection for adjuvant chemotherapy. Gene expression analysis has been shown to possess advantage over conventional staging systems in NSCLC in terms of patients risk classification. This article reviews the evidences on the genomic profiling of NSCLC patients into high and low-risk groups based on the expression of genes involved in various proliferative pathways.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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