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- Jie-Yan Zheng, Zi-Hao Wang, Zi-Yu Zhu, Zi-Han Huang, Ke-Xin Song, Bao-Lin Ye, Hai-Yun Zhou, and Shuang-Qi Gao.
- Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
- Neuroscience. 2024 Jan 26; 537: 122012-20.
AbstractThe lateral parabrachial nucleus (LPBN) is known to play a key role in relaying noxious information from the spinal cord to the brain. Different LPBN efferent mediate different aspects of the nocifensive response. However, the function of the LPBN → lateral hypothalamus (LH) circuit in response to noxious stimuli has remained unknown. Here, we show that LPBN → LH circuit is activated by noxious stimuli. Interestingly, either activation or inhibition of this circuit induced analgesia. Optogenetic activation of LPBN afferents in the LH elicited spontaneous jumping and induced place aversion. Optogenetic inhibition inhibited jumping behavior to noxious heat. Ablation of LH glutamatergic neurons could abolish light-evoked analgesia and jumping behavior. Our study revealed a role for the LPBN → LH pathway in nocifensive behaviors.Copyright © 2023 IBRO. Published by Elsevier Inc. All rights reserved.
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