• Ilari Kuitunen and Mikko Uimonen.
• University of Eastern Finland, Institute of Clinical Medicine and Department of Pediatrics, Kuopio, Finland.
• Paediatr Anaesth. 2024 Mar 1; 34 (3): 204211204-211.

ObjectiveTo analyze the optimal postextubation respiratory support in pediatric cardiac surgery patients.DesignSystematic review of randomized controlled trials.SettingPediatric or neonatal intensive care units.ParticipantsAll aged children (<16 years) having cardiac surgery and postoperative invasive ventilation.InterventionNoninvasive respiratory support, including high flow nasal cannula (HFNC), conventional oxygen therapy (COT), noninvasive positive pressure ventilation (NIPPV), continuous positive pressure (CPAP), and noninvasive high-frequency oscillatory ventilation (NHFOV).Measurement And Main ResultsStudies were not pooled for statistical synthesis due to the limited number and quality of the included studies. Risk ratios with 95% confidence intervals were calculated for individual studies. A total of 167 studies were screened and six were included. The risk of bias was low in one, high in one, and had some concerns in four of the studies. Extubation failure (defined as reintubation) was the main outcome of interest. Risk ratio for reintubation was 0.10 (CI 0.02-0.40) and 1.07 (CI 0.16-7.26) in HFNC versus COT, 0.49 (CI 0.05-5.28) in HFNC versus NIPPV, 0.40 (CI 0.08-1.94) in HFNOV versus CPAP, 0.75 (CI 0.26-2.18) in HFNOV versus NIPPV, and 1.37 (CI 0.33-5.73) in CPAP versus NIPPV. Treatment durations did not differ between the groups.ConclusionWe did not find clear evidence of a difference in reintubation rates and other clinical outcomes between different noninvasive ventilation strategies. Evidence certainty was assessed to be very low due to the risk of bias, the small number of included studies, and high imprecision. Future quality studies are needed to determine the optimal postextubation support in pediatric cardiac surgery patients.© 2023 The Authors. Pediatric Anesthesia published by John Wiley & Sons Ltd.

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