• Arch Med Sci · Jan 2023

    The transcription factor HNF-4α: a key player in haematological disorders.

    • Tareg Belali, Mosleh Abomughaid, and Muhanad Alhujaily.
    • Faculty of Applied Medical Sciences, University of Bisha, Saudi Arabia.
    • Arch Med Sci. 2023 Jan 1; 19 (6): 164616521646-1652.

    AbstractHNF-4α is a member of the steroid hormone receptor family of transcription factors with roles in the development of the liver and the regulation of several critical metabolic pathways, such as glycolysis, drug metabolism, apolipoproteins and blood coagulation. The transcriptional potency of HNF-4α is well known due to its involvement in diabetes and other metabolic diseases. However, recently HNF-4α has been discovered to be closely associated with several haematological disorders, mainly because of genetic mutations, drugs, and hepatic disorders. We review HNF-4α structure and function, and its role in haematological disorders. We discuss possible novel therapies that are based on targeting HNF-4α.Copyright: © 2021 Termedia & Banach.

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