• Gang Zhao, Arunachalam Chinnathambi, Tahani Awad Alahmadi, and Milton Wainwright.
• Department of Breast Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.
• Arch Med Sci. 2023 Jan 1; 19 (6): 185018581850-1858.

IntroductionMolecular docking as a versatile theoretical method was used to investigate the biological activities of anthraflavic acid in the presence of α-amylase. The outcomes revealed that anthraflavic acid has a considerable binding affinity to the enzyme with a docking score of -7.913 kcal/mol. These outcomes were further evaluated with free binding energy calculations, and it was concluded that anthraflavic acid could be a potential inhibitor for α-amylase.Material And MethodsAnthraflavic acid was explored in anti-human breast carcinoma tests. The in vitro cytotoxic and anti-breast carcinoma effects of biologically synthesized anthraflavic acid against MCF-7, CAMA-1, SK-BR-3, MDA-MB-231, AU565 [AU-565], and Hs 281.T cancer cell lines were assessed. In the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, the anti-breast carcinoma properties of anthraflavic acid could significantly kill the MCF-7, CAMA-1, SK-BR-3, MDA-MB-231, AU565 [AU-565], and Hs 281.T cancer cell lines in a time- and concentration-dependent manner. Also, we used human umbilical vein endothelial cells (HUVECs) to determine the cytotoxicity potentials of anthraflavic acid using MTT assay.ResultsThe IC50 values of anthraflavic acid were 159, 193, 253, 156, 241, and 218 μg/ml against MCF-7, CAMA-1, SK-BR-3, MDA-MB-231, AU565 [AU-565], and Hs 281.T cancer cell lines.ConclusionsIt seems the anti-human breast carcinoma effect of recent nanoparticles is due to their antioxidant effects.Copyright: © 2021 Termedia & Banach.

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