• Joao Emilio Lemos Pinheiro Filho, Stefanie Sophie Buuck Marque, Alexandre Cruz Henriques, Andre Roncon Dias, Jaques Waisberg, and Francisco Tustumi.
• Department of Gastroenterology, Hospital Israelita Albert Einstein, Morumbi, Brazil.
• J Coll Physicians Surg Pak. 2023 Dec 1; 33 (12): 142614321426-1432.

AbstractThis review evaluated the risks and survival benefits of pancreatoduodenectomy associated with venous resection compared with palliative surgery. A systematic review with meta-analysis was performed. Higher overall survival was observed in the pancreatic resection group (HR = 4.000; 95% CI 2.800 to 5.200). However, the palliative group had fewer complications (RD = -0.170; 95% CI -0.260 to -0.070). There was no significant difference in the mortality rates (RD = 0.000; 95% CI -0.030 to 0.030). In centres with experience in pancreatic surgery, resection may be considered for locally advanced cancer and major venous invasion. Pancreaticoduodenectomy with vascular resection may improve survival for periampullary tumours compared with palliation therapy. However, pancreaticoduodenectomy with major venous resection has potentially higher morbidity than palliation therapy. Key Words: Pancreatoduodenectomy, Pancreatic neoplasms, Vascular surgical procedures.

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