• Mahmood Al-Dhaheri, Fajer Al-Ishaq, Ali Toffaha, Mohamed Abu Nada, Amjad Parvaiz, and Mohamed Kurer.
• From the Colorectal Unit, Hamad Medical Corporation, Doha, Qatar.
• Ann Saudi Med. 2023 Nov 1; 43 (6): 348351348-351.

BackgroundAlthough transanal minimally invasive surgery (TAMIS) for rectal neoplasia has gained wide acceptance, the mid-term and long-term outcomes are not widely reported in the literature.ObjectiveDescribe the mid-term outcomes of patients who underwent TAMIS for benign and malignant rectal lesions in a single center.DesignRetrospective cohort study.SettingsTertiary referral center.Patients And MethodsDemographic, clinical, and oncological outcomes of patients who underwent TAMIS between January 2015 and December 2022 were prospectively collected. The indication for TAMIS was based on the National Comprehensive Cancer Network guidelines. The follow up for the cancer patients included clinical examination, tumor markers every 6 months and MRI rectum at the end of one year. In addition, colonoscopy and CT scan at years one and three and a final CT scan and colonoscopy at year five.Main Outcome MeasuresMid-term oncological and clinical outcome.ResultsThirty elective TAMIS procedures included adenocarcinoma for 33.3% (n=10) of the patients, 20% (n=6) neuroendocrine tumor and the 40% (n=12) were adenomatous lesions. Negative resection margins were achieved in all malignant lesions. Perioperative complications occurred in 2 patients (6.6%), one patient had breaching into the peritoneal cavity, and postoperative hypotension occurred in another patient. The median follow-up time was 23 months (range: 5-72 months). Two patients with adenoma and positive margins developed recurrent adenoma (6.6%) and one patient with initial polypectomy biopsy of adenocarcinoma, had TAMIS with histopathology of adenoma and distant metastasis had developed.ConclusionsTAMIS for local excision of rectal neoplasia is a valid option with favorable mid-term outcomes provided there is adherence to careful selection criteria.LimitationsRetrospective nature and small number of the patients.

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