• Pol. Arch. Med. Wewn. · Mar 2024

    Does the atrial fibrillation still increase the risk of death? Results from the NOMED study in one-year follow-up.

    • Katarzyna Mitrega, Beata Sredniawa, Adam Sokal, Witold Streb, Jacek Kowalczyk, Grzegorz Opolski, Tomasz Grodzicki, Krzysztof Rewiuk, Jaroslaw Kazmierczak, Lukasz Wierucki, Tomasz Zdrojewski, and Zbigniew Kalarus.
    • Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland. kas-k2@o2.pl
    • Pol. Arch. Med. Wewn. 2024 Mar 27; 134 (3).

    IntroductionAlthough atrial fibrillation (AF) is a well‑known risk factor for ischemic stroke and hospitalization, its effect on mortality has not been clearly established.ObjectivesWe aimed to assess whether AF is an independent risk factor for death. A secondary objective was to evaluate the role of oral anticoagulation in the prevention of stroke and death in 1‑year follow‑up of patients included in the NOMED‑AF (Noninvasive Monitoring for Early Detection of Atrial Fibrillation) study.Patients And MethodsThe NOMED‑AF study included 3014 patients. The participants underwent continuous long‑term electrocardiographic monitoring using a wearable vest for up to 30 days. The present analysis involved 2795 patients who completed the 1‑year follow‑up. The median (interquartile range) follow‑up time was 365 (365-365) days. AF was diagnosed in 617 participants.ResultsIndependent risk factors for death in the patients who completed the 1‑year follow‑up were AF, age equal to or above 65 years, and chronic kidney disease. The individuals with diagnosed AF had an almost 2‑fold higher risk of death (odds ratio [OR], 1.7; 95% CI, 1.18-2.44; P <0.001) and a 2.5‑fold higher risk of stroke (OR, 2.53; 95% CI, 1.41-4.44; P <0.001), as compared with those without an AF diagnosis. The participants with AF who received oral anticoagulants had an almost 5‑fold lower risk of death than those who were not on anticoagulation (2.9% vs 14.2%, respectively; P <0.001).ConclusionsAF is an independent risk factor for death and cardiovascular hospitalization. The risk of death and stroke in patients with AF is significantly higher than in the patients without this arrhythmia. Oral anticoagulation in patients with AF significantly reduces the rates of death and stroke; however, its use is suboptimal in this group of patients.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…