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- Sarah Vandelanotte and Simon F De Meyer.
- Laboratory for Thrombosis Research, KU Leuven Kulak, Kortrijk, Belgium.
- Neuroscience. 2024 Jul 9; 550: 112011-20.
AbstractIschemic stroke is caused by a thrombus blocking one or multiple arteries in the brain, resulting in irreversible damage in the associated brain tissue. The aim of therapy is to restore the blood flow as fast as possible. Two recanalization strategies are currently available: pharmacological thrombolysis using recombinant tissue plasminogen activator (rt-PA) and mechanical removal of the thrombus. Despite recent advancements, achieving efficient recanalization remains a challenge. The precise causes of therapy failure are not fully understood but thrombus composition is likely a key factor in successful recanalization. This review explores acute ischemic stroke thrombus composition, its recently identified components, and how it affects stroke treatment. It also discusses how new insights could enhance current recanalization strategies for ischemic stroke patients.Copyright © 2024 IBRO. Published by Elsevier Inc. All rights reserved.
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