• Niancheng Yu, Hong Huang, and Fang Wu.
• Department of Traditional Chinese Medicine, Children's Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310057, Zhejiang Province, China.
• Afr Health Sci. 2023 Jun 1; 23 (2): 709714709-714.

PurposeThe clinical efficacy of "Lanzhou prescription" plus or minus combined with western medicine in the treatment of children with acute aplastic anemia, 'excessive accumulation of heat toxin', was comprehensively and objectively evaluated.MethodsSixty children diagnosed with acute aplastic anemia, 'excessive accumulation of heat toxin' were divided into observation group (lanzhou prescription plus or minus combined with immunosuppressive therapy) and control group (immunosuppressive therapy alone). The relief degree of clinical symptoms and signs and the change of laboratory indicators were taken as the evaluation criteria.Results(1) After treatment, the results of remission rate of two groups treated by western medicine shows that the remission rate of the observation group was significantly higher than the control group (P< 0.05). (2) the 'cure rate' of the observation group treated for 6 months was significantly higher than treated for 3 months (P<0.05). (3) After treated for 6 months, the indexes of CD34+ cells and FOXP3+ regulatory cells in bone marrow of observation group increased, while the CD8+ cells and B cells decreased significantly, and the indexes of CD3+ cells, CD4+ cells and NK cells decreased somewhat(P<0.05).ConclusionCompared with immunosuppressive therapy, lanzhou prescription plus or minus combined with immunosuppressive therapy can alleviate the clinical symptoms and signs of children more effectively, obviously improve the Traditional Chinese Medicine symptoms of children, and help bone marrow hematopoietic stem cells gradually restore hematopoietic function.© 2023 Yu N et al.

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