• Ifeyinwa Maryann Okafor, Henshaw Uchechi Okoroiwu, and Christopher Ogar Ogar.
• Department of Haematology and Blood Transfusion Science, Faculty of Medical Laboratory Science, University of Calabar, Nigeria.
• Afr Health Sci. 2023 Jun 1; 23 (2): 265273265-273.

Introductionc-MYC plays vital role in regulation of cell proliferation and has been associated with tumorigenesis. This study is aimed at assessing diagnostic and prognostic value of plasma c-MYC expression to aid in early diagnosis and prognosis of hematological malignancies.MethodsPlasma c-MYC expression was determined by quantitative real time PCR using EVA Green chemistry and cluster of differentiation markers performed via immunocytochemistry.ResultPlasma c-MYC was higher in subject with hematological malignancies (8.8 ± 1.1) when compared with apparently healthy controls (4.5 ± 0.5). A screening cut-off c-MYC ratio value of 9.42 with sensitivity and specificity of 65.5% and 100% respectively were obtained using receiver operator characteristic curve analysis. Plasma c-MYC was found to have no prognostic value using Kaplan-Meier analysis.ConclusionPlasma c-MYC ratio showed promising screening/diagnostic value for hematological malignancies.© 2023 Okafor IM et al.

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