• African health sciences · Jun 2023

    Randomized Controlled Trial

    Effects of ozone combined with articular injection of sodium hyaluronate on patients with knee osteoarthritis and their inflammatory factors and hemorheological indices.

    • Chengyong Yang and Qun Chen.
    • Department of Orthopedics, Affiliated Hospital of Yangzhou University, Yangzhou 225000, Jiangsu Province, China.
    • Afr Health Sci. 2023 Jun 1; 23 (2): 360366360-366.

    ObjectiveKnee osteoarthritis (KOA) is a common chronic progressive disease. We aimed to evaluate the effects of ozone combined with articular injection of sodium hyaluronate on KOA patients and their inflammatory factors and hemorheological indices.MethodsA total of 292 KOA patients treated from October 2020 to October 2021 were randomly divided into observation and control groups (n=146). Observation group was treated with ozone combined with articular injection of sodium hyaluronate, while control group was routinely given glucosamine hydrochloride tablets and articular injection of sodium hyaluronate. The treatment was performed once a week for 5 consecutive weeks. Their general data, treatment outcomes, visual analogue scale (VAS) score, Hospital for Special Surgery (HSS) knee score, inflammatory factor levels and hemorheological indices were compared.ResultsAfter treatment, observation group had significantly lower VAS score and higher HSS score than those of control group (P<0.05). The total response rate of observation group was higher than that of control group (P<0.05). The levels of inflammatory factors in the joint fluid were significantly lower in observation group than those in control group (P<0.05). The hemorheological indices were improved in both groups, especially in observation group (P<0.05).ConclusionOzone combined with articular injection of sodium hyaluronate has obvious therapeutic effects on KOA.© 2023 Yang C et al.

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