• Jie Huang, Jiaheng Han, Rigbat Rozi, Bensheng Fu, Zhengcao Lu, Jiang Liu, and Yu Ding.
• Orthopaedics of TCM Senior Department, The Sixth Medical Center of PLA General Hospital, Beijing 100048, China; Department of Orthopaedics, School of Medicine, South China University of Technology, Guangzhou 510006, China.
• Prev Med. 2024 Mar 1; 180: 107861107861.

ObjectiveUsing cross-sectional data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES) for American, the aim of this research is to investigate the potential association between Lipid Accumulation Products (LAP) and the risk of osteoarthritis (OA).MethodsData from the NHANES (2017-2020) were downloaded and further analyzed. The participants between 20 and 80 years reported having OA, and other relevant variables and information on LAP were included. The linear and non-linear associations between LAP and OA were evaluated using multivariable logistic regression analysis and smoothed curve fitting methods. A two-part linear regression model was also used to estimate threshold effects.ResultsThe increased risk of OA was shown to have a nonlinear relationship with higher LAP, showing a solid threshold impact with a saturation value of 120.00 cm × mmol/L, according to our data. The two variables showed a positive relationship to the left of the saturation point but no significant association to the right, pointing to a complicated nonlinear relationship between OA prevalence and LAP.ConclusionsOur findings revealed that LAP was an independent risk factor for OA when it was <120.00 cm × mmol/L. The LAP index may serve as a valuable method for predicting and diagnosed OA. To validate our results, further large-scale prospective research are required.Copyright © 2023. Published by Elsevier Inc.

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