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Chinese medical journal · Aug 2024
ReviewRegulation of fatty acid synthase on tumor and progress in the development of related therapies.
- Rilan Bai and Jiuwei Cui.
- Cancer Center, the First Hospital of Jilin University, Changchun, Jilin 130021, China.
- Chin. Med. J. 2024 Aug 20; 137 (16): 189419021894-1902.
AbstractFatty acid synthase (FASN) is an essential molecule in lipid metabolic pathways, which are crucial for cancer-related studies. Recent studies have focused on a comprehensive understanding of the novel and important regulatory effects of FASN on malignant biological behavior and immune-cell infiltration, which are closely related to tumor occurrence and development, immune escape, and immune response. FASN-targeting antitumor treatment strategies are being developed. Therefore, in this review, we focused on the effects of FASN on tumor and immune-cell infiltration and reviewed the progress of related anti-tumor therapy development.Copyright © 2024 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.
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