• Yo Han Kim, Yun Rak Choi, Dong Jin Joo, Woo Yeol Baek, Young Chul Suh, Won Taek Oh, Jae Yong Cho, Sang Chul Lee, Sang Kyum Kim, Hyang Joo Ryu, Kyung Ock Jeon, Won Jai Lee, and Jong Won Hong.
• Department of Plastic & Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Korea.
• Yonsei Med. J. 2024 Feb 1; 65 (2): 108119108-119.

PurposeWith the revision of the Organ and Transplantation Act in 2018, the hand has become legal as an area of transplantable organs in Korea. In January 2021, the first hand allotransplantation since legalization was successfully performed, and we have performed a total of three successful hand transplantation since then. By comparing and incorporating our experiences, this study aimed to provide a comprehensive reconstructive solution for hand amputation in Korea.Materials And MethodsRecipients were selected through a structured preoperative evaluation, and hand transplantations were performed at the distal forearm level. Postoperatively, patients were treated with three-drug immunosuppressive regimen, and functional outcomes were monitored.ResultsThe hand transplantations were performed without intraoperative complications. All patients had partial skin necrosis and underwent additional surgical procedures in 2 months after transplantation. After additional operations, no further severe complications were observed. Also, patients developed acute rejection within 3 months of surgery, but all resolved within 2 weeks after steroid pulse therapy. Motor and sensory function improved dramatically, and patients were very satisfied with the appearance and function of their transplanted hands.ConclusionHand transplantation is a viable reconstructive option, and patients have shown positive functional and psychological outcomes. Although this study has limitations, such as the small number of patients and short follow-up period, we should focus on continued recovery of hand function, and be careful not to develop side effects from immunosuppressive drugs. Through the present study, we will continue to strive for a bright future regarding hand transplantation in Korea.© Copyright: Yonsei University College of Medicine 2024.

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