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- Juri Kawasaki, Naoko Mato, Hiroyuki Fujii, Kumiko Miura, Takafumi Mashiko, Shinshu Katayama, Yoshitaka Yamanouchi, Miki Sato, Toshikazu Takasaki, Ayako Takigami, Shu Hisata, Shin Nunomiya, Koichi Hagiwara, and Makoto Maemondo.
- Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.
- Intern. Med. 2024 Apr 15; 63 (8): 116711721167-1172.
AbstractA 45-year-old woman was hospitalized with severe coronavirus disease 2019 pneumonia. Following cytokine storm-induced multiorgan failure and lethal arrhythmia, the patient developed a sustained coma with flaccid quadriplegia. A cerebrospinal fluid examination excluded infectious and immunogenic encephalopathies, and diffusion-weighted magnetic resonance imaging demonstrated high-intensity areas in the white matter with a cortex-sparing distribution, suggesting delayed post-hypoxic leukoencephalopathy. As a result of intensive cardiopulmonary support for a month, the neurological function gradually recovered. Based on the reversible clinical course noted in this patient, accurate diagnosis and persistent medical approaches are important for the management of coronavirus disease 2019-related delayed post-hypoxic leukoencephalopathy.
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