• Acta clinica Croatica · Apr 2023

    COMPARISON OF C-REACTIVE PROTEIN LEVELS IN SERUM AND PERITONEAL FLUID IN EARLY DIAGNOSIS OF ANASTOMOTIC LEAKAGE AFTER COLORECTAL SURGERY.

    • Dubravka Mužina Mišić, Mario Zovak, Mario Kopljar, Slaven Čiček, and Zdenko Bilić.
    • Department of Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
    • Acta Clin Croat. 2023 Apr 1; 62 (1): 111811-18.

    AbstractIn colorectal surgery, anastomotic leakage is a serious complication, leading to higher postoperative morbidity and mortality. The aim of this study was to evaluate the accuracy of serum and intraperitoneal C-reactive protein (CRP) in early diagnostics of anastomotic leakage on the first four postoperative days after colorectal surgery. From January to October 2019, fifty-nine patients with colorectal carcinoma were operated on, with formation of primary anastomosis. Anastomotic leakage was diagnosed in eight patients. Comparing the levels of serum and intraperitoneal CRP, our study showed that serum CRP was a better predictor of anastomotic leakage. Serum CRP levels lower than 121 mg/L on postoperative day 4 were predictive of good healing of anastomosis.Sestre Milosrdnice University Hospital.

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