• Cleve Clin J Med · Feb 2024

    Review

    von Willebrand disease: A guide for the internist.

    • Varinder Kaur, Omar Elghawy, Saarang Deshpande, and David Riley.
    • Associate Professor, Department of Internal Medicine, Division of Hematology and Oncology, University of Virginia, Charlottesville, VA vk4q@virginia.edu.
    • Cleve Clin J Med. 2024 Feb 2; 91 (2): 119127119-127.

    Abstractvon Willebrand disease (VWD), the most common inherited bleeding disorder, results when patients either do not make enough von Willebrand factor (VWF) or make defective VWF. The pathophysiology of this disorder is complex but needs to be understood to interpret the diagnostic tests. Most patients have mild to moderate symptoms and can be adequately counseled and managed by a general internist, but some need to consult a hematologist. We review the pathophysiology of VWD, its subtypes, common presentations of each subtype, diagnostic testing, and management of mild as well as severe clinical manifestations of VWD.Copyright © 2024 The Cleveland Clinic Foundation. All Rights Reserved.

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