• Cleve Clin J Med · Feb 2024

    Review

    Management of venous thromboembolism in patients with active cancer.

    • Heloni M Dave and Alok A Khorana.
    • Department of Hematology and Medical Oncology, Taussig Cancer Institute and Case Comprehensive Cancer Center, Cleveland Clinic, Cleveland, OH; PGY-1 Internal Medicine, Cleveland Clinic Akron General, Akron, OH.
    • Cleve Clin J Med. 2024 Feb 2; 91 (2): 109117109-117.

    AbstractVenous thromboembolism (VTE) is a major health burden in patients with cancer, causing morbidity, emergency room visits, hospitalizations, and death. Treatment is challenging, as it is necessary to balance the risk of recurrent thrombosis and bleeding associated with anticoagulants. Treatment paradigms are shifting from low-molecular-weight heparin monotherapy. Multiple recent randomized controlled trials have demonstrated the safety and efficacy of direct oral anticoagulants in this setting. Current studies are evaluating factor XI inhibitors as potential treatments for cancer-associated VTE.Copyright © 2024 The Cleveland Clinic Foundation. All Rights Reserved.

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