• Nasser Almutairi, Alanoud Alshathri, Waleed Alshareef, Abdullah Sindi, Abdullah Aljasser, and Ahmed Alammar.
• From the Department of Otolaryngology-Head and Neck Surgery (Almutairi), King Faisal Specialist Hospital and Research Center, from the Department of Otolaryngology-Head and Neck Surgery (Almutairi, Alshathri, Alshareef, Sindi, Aljasser, Alammar), King Saud University Medical City, and from the College of Medicine (Almutairi), Alfaisal University, Riyadh, Kingdom of Saudi Arabia.
• Saudi Med J. 2024 Feb 1; 45 (2): 205210205-210.

ObjectivesTo study the clinical evaluation of recurrent respiratory papillomatosis (RRP) patients and the factors associated with the improvement in the Derkay's score as a measure of disease severity.MethodsA retrospective cohort that included all juvenile RRP patients who were admitted to King Abdulaziz University Hospital, Riyadh, Saudi Arabia, between September 2015 and June 2022 and underwent surgical debulking.ResultsA total of 16 patients were eligible to join our study. Among them, 7 patients were males. Hoarseness of voice was the most frequent symptom. The median period of the follow-up was 56 months. Complete remission was achieved in 31.3%. The univariate linear regression model revealed that the cidofovir-treated patients had a significant reduction in the change value of Derkay's score compared to those without treatment (regression coefficient= -5.83, 95% confidence interval [CI]: [-11.5 to -0.143], p=0.045). Also, the increased first Derkay's score decreased the change value and subsequently increased the improvement chance of the disease (regression coefficient= -0.424, 95% CI: [-0.764 to -0.083], p=0.018). However, in the multivariate regression model, both variables showed non-significant results.Conclusioncidofovir treatment and higher Derkay's scores affected the disease improvement.Copyright: © Saudi Medical Journal.

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