• Bojana Radulović, Ines Potočnjak, Sanda Dokoza Terešak, Matias Trbušić, Nada Vrkić, Azra Huršidić Radulović, Neven Starčević, Milan Milošević, Vesna Degoricija, and Saša Frank.
• 1Zagreb University Hospital Centre, Zagreb, Croatia; 2Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 3University of Zagreb School of Medicine, Zagreb, Croatia; 4University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia; 5Occupational Medicine Office, Zagreb, Croatia; 6Sveti Duh University Hospital, Zagreb, Croatia; 7Andrija Štampar School of Public Health, University of Zagreb School of Medicine, Zagreb, Croatia; 8Institute of Molecular Biology and Biochemistry, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria.
• Acta Clin Croat. 2019 Jun 1; 58 (2): 195201195-201.

AbstractDetecting predictors of poor outcome is crucial for understanding the underlying pathophysiology of heart failure (HF) and thus creating new therapeutic concepts. It is well established that low serum lipid levels are associated with unfavorable outcomes in HF patients. Several studies examined the association between serum lipids and established predictors of mortality in HF patients. The aim of the present study was to examine the association of serum lipid and chloride concentrations, as well as their impact on survival in acute heart failure (AHF). The present study was performed as a prospective, single-centre, observational research. The study included 152 patients with AHF. Spearman's correlation coefficient revealed a significant positive correlation of serum chloride levels with serum levels of total cholesterol (ρ 0.221, p=0.006), low-density lipoprotein cholesterol (LDL-c) (ρ 0.187, p=0.015) and high-density lipoprotein-cholesterol (HDL-c) (ρ 0.169, p=0.038). Binary logistic regression revealed a significant association of chloride, total cholesterol and LDL-c serum levels measured at admission with hospital survival (OR 1.077, CI 1.01-1.154, p=0.034), (OR 1.731, CI 1.090-2.748, p=0.020) and (OR 1.839, CI 1.033-3.274, p=0.038), respectively, as well as with 3-month survival (OR 1.065, CI 1.002-1.131, p=0.042), (OR 1.625, CI 1.147-2.303, p=0.006) and (OR 1.711, CI 1.117-2.622, p=0.014), respectively. In conclusion, positive statistical association between serum cholesterol (total cholesterol, LDL-c and HDL-c) and chloride levels may suggest their similar modulation by AHF pathophysiology. Serum levels of total cholesterol, LDL-c and chloride contribute to patient survival.

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