• Kizito Omona and Albert Mucha Opiyo.
• Faculty of Health Sciences, Uganda Martyrs University, Kampala, Uganda.
• Afr Health Sci. 2023 Sep 1; 23 (3): 343357343-357.

BackgroundMulti-drug resistant tuberculosis (MDR-TB) is increasingly recognized as emerging infectious disease of public health concern. Globally, 206030 people were diagnosed with MDR-TB in 2019, representing a 10% increase from 186883people who had it in 2018. In Uganda, the prevalence of MDR among new TB cases is 4.4% and 17.7% among previously treated TB cases.AimTo determine the risk factors associated with MDR-TB among tuberculosis patients in Gulu regional referral hospital.Material And MethodsA cross-sectional analytical study using both quantitative and qualitative methods of data collection and analysis was used. Data was collected from 384 TB patients using data extraction form and 6 Key informant interviews conducted. Analysis using Pearson chi-square test was run.ResultsHIV positive patients were 2.6 times more likely to be infected with MDR-TB than HIV negative patients [AOR=2.6: 95% CI 1.34- 5.85: P=0.006]. Previously treated TB patients were 2.8 times more likely to be infected with MDR-TB than newly diagnosed TB patients [AOR=2.8: 95% CI 1.33- 5.85: P=0.006]. Defaulting TB patients were 3.1 times more likely to be infected with MDR-TB than the non-defaulting TB patients [AOR=3.1].ConclusionThere is high prevalence of drug resistance among patients attending TB treatment at the facility.© 2023 Omona K et al.

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