• Peidong Yue, Lei Zhang, and Bin Wang.
• Department of Neurosurgery, Suzhou Hospital of Anhui Medical University (Suzhou Municipal Hospital of Anhui Province), Suzhou 234000, Jiangsu Province, China.
• Afr Health Sci. 2023 Sep 1; 23 (3): 561568561-568.

ObjectiveTo evaluate the effects of interventional vascular embolization at different timing on the prognosis and serum S100 calcium-binding protein B (S100B) level of patients with aneurysmal subarachnoid hemorrhage (aSAH).MethodsA total of 229 aSAH patients enrolled from January 2016 to January 2020 were divided into an early-stage group (n=66), a middle-stage group (n=95) and a late-stage group (n=68. Their baseline data, serum indices and clinical outcomes were compared. The factors affecting their prognosis were analysed. The value of serum S100B level for predicting the prognosis was evaluated.ResultsThe early-stage group had the highest GOS score, and the late-stage group had the lowest score (P<0.05). Older age, large diameter of aneurysm, high Hunt-Hess grade upon admission, late surgical treatment and high S100B level were risk factors for the poor prognosis of aSAH patients. The optimal cut-off value of S100B for predicting the prognosis was 2.785 [µg/L. The area under the receiver operator characteristic curve, sensitivity, specificity, Youden index and 95% confidence interval were 0.892, 84.3%, 86.3%, 0.706 and 0.844-0.940, respectively.ConclusionEarly vascular interventional embolization is beneficial to the alleviation of brain injury and the reduction of serum S100B level.© 2023 Yue P et al.

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