• Li Wu, Peng Shi, Yujie Zhao, Di Shao, and Hongliang Wu.
• Li Wu, Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui Province 233004, P.R. China.
• Pak J Med Sci. 2024 Jan 1; 40 (3Part-II): 342346342-346.

ObjectiveTo investigate hemorheology and inflammatory marker changes after treatment for acute ischemic stroke (AIS) using intravenous thrombolysis (IVT) with mechanical thrombectomy (MT).MethodsWe retrospectively reviewed clinical records of patients with AIS (n=83) treated in The First Affiliated Hospital of Bengbu Medical College between January 2021 and December 2022 (n=83). The control group consisted of 38 patients who underwent IVT alone and the observation group consisted of 45 patients who underwent IVT with MT. We compared differences in mean variables related to hemorheology, inflammatory markers, and total efficacy between the two groups.ResultsWe found that hemorheology values (plasma viscosity [PV], whole blood viscosity [WBV], fibrinogen [FIB], and hematocrit [HCT]), and the levels of inflammatory markers (tumor necrosis factor ɑ [TNF-ɑ] and interleukin-6 [IL-6]) were higher in the control group than in the observation group after treatment (P<0.05). In addition, the total efficacy of the observation group (93.3%) was higher than that in the control group (76.3%; P=0.016).ConclusionsThe clinical efficacy of combined IVT and MT in the treatment of AIS is superior to IVT alone, improving levels of hemorheology and inflammatory markers in patients with AIS.Copyright: © Pakistan Journal of Medical Sciences.

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