• Pak J Med Sci · Jan 2024

    Relationship between baseline mean platelet volume (MPV) and prognosis of patients with acute mild cerebral infarction undergoing intravenous thrombolysis with Alteplase.

    • Yanhao Wang, Xiaoqing Wei, Wei Du, and Congcong Yuan.
    • Yanhao Wang, Department of Neurology, Baoding No.1 Central Hospital, Baoding 071000, Hebei, China.
    • Pak J Med Sci. 2024 Jan 1; 40 (3Part-II): 318325318-325.

    ObjectiveTo investigate the relationship between baseline, mean platelet volume (MPV) and prognosis of patients with acute mild cerebral infarction undergoing intravenous thrombolysis with alteplase.MethodsA retrospective analysis was conducted of clinical imaging and laboratory data of patients with acute mild cerebral infarction who received intravenous thrombolytic therapy with alteplase in Baoding No.1 Central Hospital between March 2018 and March 2021. According to mRS scores after three months, a total of 140 patients were divided into the good prognosis group(n=115) (mRS score ResultsLogistic regression analysis showed that 24 hour NIHSS score after thrombolysis and baseline MPV were independently correlated with 3-month prognosis. The ROC curve indicated an optimal cutoff value of 9.65 fl for MPV in predicting poor prognosis. The study also found that the increase of baseline MPV had a close bearing on the risk increase of END.ConclusionBaseline MPV is an independent risk factor for early neurological deterioration and three months poor prognosis in patients with acute mild cerebral infarction undergoing intravenous thrombolysis.Copyright: © Pakistan Journal of Medical Sciences.

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