• Pak J Med Sci · Jan 2024

    Comparison of the efficacy of combining left bundle branch pacing with either sacubitril/valsartan or enalapril in the treatment of chronic heart failure: A retrospective observational analysis.

    • Shengping Wang, Yongsheng Feng, Xiangyang Sun, Hualiang Gou, and Yong Guo.
    • Shengping Wang, Department of Cardiology, Dazhou Central Hospital,Dazhou, Sichuan Province, 635000, China.
    • Pak J Med Sci. 2024 Jan 1; 40 (3Part-II): 265270265-270.

    ObjectiveTo assess the efficacy of left bundle branch pacing (LBBP) combined with either sacubitril/valsartan or enalapril in the treatment of chronic heart failure (CHF).MethodsWe retrospectively reviewed the records of 138 patients with CHF admitted to Dazhou Central Hospital between June 2020 and June 2022 to extract clinical data. We divided the data into two treatment groups for the analysis: 71 patients received LBBP combined with sacubitril/valsartan treatment (sacubitril/valsartan group), and 67 received LBBP combined with enalapril treatment (enalapril group). The levels of cardiac and cardiopulmonary function indicators, levels of myocardial injury markers, and the scores of the Minnesota Living with Heart Failure Questionnaire (MLHFQ) before and after the treatment were compared between the two groups.ResultsAfter six months of treatment, patients in the sacubitril/valsartan group had lower myocardial injury markers, higher cardiopulmonary function indicators, and lower MLHFQ scores (P<0.05).ConclusionsIn CHF patients, the combination of LBBP with sacubitril/valsartan had a better therapeutic effect compared to LBBP with enalapril, with more effective improvement of the cardiopulmonary function, reduction of myocardial injury, and improvement in quality of life.Copyright: © Pakistan Journal of Medical Sciences.

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