• Mohammad Masood, Riaz Hussain Channa, and Nazish Butt.
• Dr. Mohammad Masood, MBBS, FCPS (Gastroenterology & Hepatology). Assistant Professor, Department of Gastroenterology & Hepatology Jinnah Postgraduate Medical Center, Karachi, Pakistan.
• Pak J Med Sci. 2024 Jan 1; 40 (3Part-II): 482486482-486.

ObjectiveThe objective of this study was to find out frequency and risk factors of malabsorption in patients presenting at tertiary care hospital, Karachi.MethodsThis was a prospective-observational study conducted through a non-probability consecutive sampling technique. Ninety two adult patients presenting with a history of chronic diarrhea (diarrhea having duration of more than four weeks), age ≥14 years, both males & females, and diagnosed as malabsorption syndrome visiting out-patient or admitted in the department of Gastroenterology of the Jinnah Postgraduate Medical Center, Karachi between June 2018 and July 2020 were enrolled. Baseline and clinical data were recorded in a pre-designed questionnaire and analyzed using statistical package for the social sciences (SPSS) version 21.0.ResultsThe overall mean age and standard deviation of patient was 35.42±10.83 years. Diarrhea n=71 (77.17%), fever n=35 (38.04%), abdominal pain n=32 (34.78%), and weight loss n=13 (14.13%) were the most common symptoms observed in our study subjects. Most of the patients had normal upper GI endoscopy (26.56%) while multiple fundal erosions with pre-pyloric ulcer and severe pangastric erythema & classical scalloping of duodenal folds were most common findings observed, 21.87% and 17.18%, respectively.ConclusionOur study provides evidence that malabsorption syndrome is most commonly present in males with younger age group and the most common causes were celiac disease and intestinal tuberculosis and most common presentation was diarrhea, fever, and abdominal pain.Copyright: © Pakistan Journal of Medical Sciences.

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