• Morteza Hassanzadeh, SanatZahra MomayezZMDepartment of Internal Medicine, School of Medicine, Digestive Diseases Research Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran., Somayeh Khayatian, Mohammadjavad Sotoudeheian, Amirmasoud Shahbazian, and SeyedAhmad Hoseini.
• Department of Internal Medicine, School of Medicine, Colorectal Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran. Electronic address: Hassanzadeh.m@iums.ac.ir.
• J Natl Med Assoc. 2024 Apr 1; 116 (2 Pt 1): 119125119-125.

AbstractSickle cell disease (SCD) is an inherited hemoglobinopathy with protean clinical manifestations. The liver could be affected by various SCD-associated complications of an overlapping nature. The clinical presentations of "sickle cell hepatopathy" range from clinically asymptomatic patients to those with life-threatening complications. Herein we report an SCD patient who presented with right upper quadrant abdominal pain and jaundice, eventually diagnosed as a self-limited form of acute sickle cell hepatopathy with overlapping features of acute hepatic crisis and benign intrahepatic cholestasis. Using this patient as an illustration, we will review the spectrum of hepatobiliary presentations in the SCD population.Copyright © 2024. Published by Elsevier Inc.

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