• Hongjun Jia, Hengwang Yu, and Qingzhan Liu.
• Department of Radiotherapy, Linyi Peoples' Hospital, Linyi, China - qingzhan_liu@126.com.
• Minerva Med. 2016 Apr 27.

BackgroundSingle nucleotide polymorphism in miRNAs can alter its expression, thus lead to the development of cancers. Numerous studies have explored the association between miR-149 gene rs2292832 polymorphism and hepatocellular carcinoma risk, but the results remains inconsistent. So, we performed this pooled analyses in order to get a precise result.MethodsOdds ratios (OR) with 95% confidence intervals (CI), calculated by STATA software, were used to determine whether miR-149 gene rs2292832 polymorphism contributes to the risk of Hepatocellular carcinoma. A comprehensive literature search was conducted on Medline (mainly PubMed), Cochrane Library database, Web of science and the China National Knowledge Internet (CNKI) up to March 22, 2016.ResultsA total of 20 studies including 8,201 cases and 9,294 controls were included in this meta-analysis. Four of 20 studies related to the hepatocellular carcinoma risk. When all the eligible studies were pooled into this meta-analysis, a significant association between miR-149 gene rs2292832 polymorphism and hepatocellular carcinoma risk was found. While no association was found between this gene polymorphism and overall cancer risk.ConclusionsOur meta-analysis supports that the miR-149 gene rs2292832 polymorphism contributed to the risk of hepatocellular carcinoma from currently available evidence. However, a study with a larger sample size is needed to further evaluate gene-environment interaction on MiR-149 gene rs2292832 polymorphism and hepatocellular carcinoma risk.

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