• Arch Med Sci · Jan 2024

    Obesity and lung cancer - is programmed death ligand-1 (PD-1L) expression a connection?

    • Jakub Krzysztof Gałązka, Marcin Czeczelewski, Tomasz Kucharczyk, Katarzyna Szklener, and Sławomir Mańdziuk.
    • Students' Scientific Association at Chair of Clinical Oncology and Chemotherapy, Medical University of Lublin, Lublin, Poland.
    • Arch Med Sci. 2024 Jan 1; 20 (1): 313316313-316.

    IntroductionIn this retrospective study, the authors evaluated whether obesity-induced immunomodulation impacts the expression of programmed death ligand-1 (PD-1L) in lung cancer cells.Methods: A retrospective cross-sectional study was performed. The study included 67 patients. The data did not have a normal distribution.ResultsFor women, using ANOVA test (p = 0.050) with post-hoc analysis, a statistically significant difference in expression was found between women with overweight and women with normal weight (p = 0.040).ConclusionsApart from the above, the authors did not find any statistically significant correlation between PD-1L expression on lung cancer cells and body mass index, either in the whole group or in histological subgroups.Copyright: © 2024 Termedia & Banach.

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