• Internal medicine · Jan 2015

    Case Reports

    Atypical progressive multifocal leukoencephalopathy in a patient with antisynthetase syndrome.

    • Moncef Belhassen-Garcia, Alberto Rábano-Gutiérrez, Virginia Velasco-Tirado, Angela Romero-Alegria, Maria-Luisa Pérez-Garcia, and Jose Angel Martin-Oterino.
    • Department of Internal Medicine, Unit of Infectious Diseases. IBSAL. University Hospital of Salamanca. CIETUS, University of Salamanca, Spain.
    • Intern. Med. 2015 Jan 1;54(5):519-24.

    AbstractAntisynthetase syndrome is a disorder belonging to the dermatomyositis/polymyositis group, with high rates of morbidity and mortality. We herein present the case of a 71-year-old man who was diagnosed with antisynthetase syndrome and treated with rituximab. Almost three years later, the patient showed right-sided hemiparesis that ultimately progressed to complete hemiplegia and advancing cognitive deterioration with a poor clinical outcome. The neuropathological diagnosis was progressive multifocal leukoencephalopathy. Treatment with rituximab for antisynthetase syndrome itself plays a fundamental role in the development of infectious complications.

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