• Medicine · Mar 2024

    Review

    The role of mitochondrial transfer via tunneling nanotubes in the central nervous system: A review.

    • Ye Chen, Dongqiong Xiao, and Xihong Li.
    • Department of Emergency Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
    • Medicine (Baltimore). 2024 Mar 1; 103 (9): e37352e37352.

    AbstractTumour necrosis factor alpha-induced protein 2 (TNFAIP2) is a gene induced by tumor necrosis factor in endothelial cells. TNFAIP2 has important functions in physiological and pathological processes, including cell proliferation, adhesion, migration, angiogenesis, inflammation, tunneling nanotube (TNT) formation and tumorigenesis. Moreover, TNFAIP2 is the key factor in the formation of TNTs. TNTs are related to signal transduction between different cell types and are considered a novel means of cell-to-cell communication. Mesenchymal stem cells (MSCs) are pluripotent cells that exhibit self-renewal, multidirectional differentiation, paracrine function and immune-regulating ability. MSCs can transfer mitochondria through TNTs to improve the functions of target cells. This review revealed that TNFAIP2 promotes the formation of TNTs and that MSCs rely on TNTs for mitochondrial transfer to ameliorate cell dysfunction.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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