• Jaudah A Al-Maghrabi.
• From the Department of Pathology, Faculty of Medicine, King Abdulaziz University; and from the Department of Pathology, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi Arabia.
• Saudi Med J. 2024 Mar 1; 45 (3): 307312307-312.

ObjectivesTo report the histopathological pattern of primary pancreatic lymphoma (PPL) in 2 tertiary hospitals.MethodsThe pathology slides and reports of all the cases diagnosed in pathology departments in 2 referral hospitals were reviewed. An additional immunohistochemistry study was done to reclassify lymphomas according to the current system.ResultsEight patients with PPL have been identified. The ages ranged from 36 to 71 years. Clinical presentation includes abdominal pain, weight loss, jaundice, abdominal mass, nausea, and vomiting. Pathological evaluation revealed 5 diffuse large B-cell lymphomas, one high-grade B-cell lymphoma, one MALT lymphoma, and one follicular lymphoma.ConclusionPrimary pancreatic lymphoma is a very rare tumor without specific clinical, laboratory tests, or radiological findings. Abdominal pain is the most common clinical presentation. Diffuse large b-cell lymphoma is the most common pathological subtype. Primary pancreatic lymphoma should be taken into consideration when evaluating pancreatic mass to avoid unnecessary surgical resection.Copyright: © Saudi Medical Journal.

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