• Khalid H Sait, Nisreen M Anfinan, Hesham K Sait, and Hussain A Basalamah.
• From the Department of Obstetrics and Gynecology (K. Sait, Anfinan, H. Sait, Basalamah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; and from the Tom Baker Cancer Center (H. Sait), University of Calgary, Alberta, Canada.
• Saudi Med J. 2024 Mar 1; 45 (3): 252260252-260.

ObjectivesTo estimate the prevalence and dynamics of human papillomavirus (HPV) infection, over a 5-year period, among Saudi women.MethodsA 2-phase, population-based study combining cross-sectional and cohort designs was carried out with 5360 ever-married women aged 30-65 from Jeddah, Saudi Arabia, between 2013 and 2018. Participants were enrolled in a designated screening program and screened using the hybrid capture 2 HPV test. Women testing positive for HPV were followed up after one year to estimate the HPV clearance rate, while those testing negative had a follow-up after 5 years to assess new HPV infections. Factors associated with HPV positivity and clearance, including sociodemographic and clinical aspects, were analyzed.ResultsParticipant's mean age was 44.3 and the average marriage duration was 22.6 years. The initial HPV prevalence was 4.7%. After one year, the HPV clearance rate among initially positive women was 84.3%. The rate of new HPV infections among initially negative women after 5 years was 0.2%, resulting in a cumulative HPV prevalence of 5% over the study period. The incidence rate was estimated at 47 per 100,000 person-years. Parity was the only independent factor inversely associated with HPV positivity, with an odds ratio of 0.93 (95% confidence interval: 0.8 - 0.99).ConclusionThe prevalence of HPV in Saudi women was relatively low, suggesting a low transmission rate of HPV. This finding indicates the need for continuous monitoring and tailored prevention strategies.Copyright: © Saudi Medical Journal.

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