• Márcio Antônio Mendonça, Sandra Fernandes Arruda, Ernandes Rodrigues de Alencar, and Wilma Maria Coelho Araújo.
• Faculty of Agronomy and Veterinary Medicine, University of Brasília, Brasília, Campus Darcy Ribeiro, Asa Norte, Brasília, Brazil.
• Nutrition. 2024 May 1; 121: 112264112264.

ObjectivesThe lipid fraction, fatty acid profile, and diameter of fat globules of infant formulas show great differences from human milk. These characteristics influence fat digestion and, consequently, the development and health of infants. The aim of this study was to evaluate the diameter of fat globules in infant formulas and compare them with those in human milk.MethodsThe diameter of fat globules of 10 infant formulas and human milk samples was determined using scanning electron microscopy.ResultsThe starter infant formula was the only one that showed a mean diameter value (3.52 ± 2.17 µm) similar to that obtained for human milk (3.44 ± 1.68 µm). The starter infant formula showed the highest values of volume-surface D3,2 (6.13 µm) and volume-weighted D4,3, (7.05 µm) mean diameters among the infant formulas analyzed, and close to those obtained for the human milk sample (5.16 and 5.98 µm, respectively). The infant formulas whey protein partially hydrolyzed, soy protein isolate-based, whey protein extensively hydrolyzed, and thickened with pregelatinized starch had the lowest mean diameters of fat globules 0.64 ± 0.22, 0.70 ± 0.19, 1.06 ± 0.34, and 1.22 ± 0.48 µm, respectively.ConclusionThe analysis of principal components showed that none of the analyzed infant formulas had similarity with the diameter of fat globules and the fatty acid profile of human milk.Copyright © 2023. Published by Elsevier Inc.

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