• Ying Zhou, Jun Yang, Hong Hai, Jun Dong, and Ying Wen.
• Department of Infectious Diseases II, Shenyang Natural Focal Diseases Clinical Medical Research Center, The First Affiliated Hospital of China Medical University. No. 155, Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China.
• Medicine (Baltimore). 2024 Mar 8; 103 (10): e37332e37332.

RationaleHemorrhagic fever with renal syndrome (HFRS) is a common infectious disease in China. As a complication of post-Hantavirus infection, Guillain-Barre syndrome (GBS) was rarely previously reported. Here, we described a case of acute inflammatory demyelinative polyradiculoneuropathy secondary to Hantavirus infection in spring of 2023. We also made a summary of the clinical features from previous reported cases.Patient ConcernsA young male patient complained a fever with headache, who was subsequently diagnosed with HFRS with positive serum Hantavirus antibody IgM. Two weeks later, he presented sustained back pain, obvious numbness located in 4 extremities, chest and abdomen, facial dyskinesia and 4 extremities muscle weakness.Diagnosis, Interventions, And OutcomesHe was rapidly diagnosed with GBS by typical cerebrospinal fluid change and the electromyography examination presentation, which was verified associated with hantavirus infection. He was treated with intravenous immunoglobulin infusion followed by rehabilitation treatment. He got a complete recovery within 4 months after disease onset.LessonsGBS was an uncommon manifestation of Hantavirus infection. GBS should be considered when acute limb weakness happens in cases with HFRS. A multidisciplinary team could make a rapid diagnosis and optimal treatment when nervous system disorders occurred.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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