• J Coll Physicians Surg Pak · Mar 2024

    Association of Oral Submucous Fibrosis Risk with GSTM1 and GSTT1 Gene Polymorphisms.

    • Abdul Mannan, Munir Ahmad Bhinder, Haleema Sadia, Zainab Yousaf, Zawar Hussain, Muhammad Akram, Madiha Shakoor, Muhammad Yasir Zahoor, and Rahat Abdul Rehman.
    • Department of Human Genetics and Molecular Biology, University of Health Sciences, Lahore, Pakistan.
    • J Coll Physicians Surg Pak. 2024 Mar 1; 34 (3): 296301296-301.

    ObjectiveTo determine the association of GSTM1 and GSTT1 polymorphisms with oral submucous fibrosis (OSF).Study DesignA case-control study. Place and Duration of the Study: Department of Human Genetics and Molecular Biology, University of Health Sciences, Lahore and Oral and Maxillofacial Surgery Department, de Montmorency, College of Dentistry/ Punjab Dental Hospital, Lahore, Pakistan, from 1st April 2019 to 31st April 2020.MethodologyOSF patients were diagnosed with different clinical staging of mouth opening by Vernier caliper with the help of a professional dentist in the Department of Oral and Maxillofacial, de Montmorency, College of Dentistry, Lahore. One hundred and eight blood samples of OSF patients and 108 samples of normal controls were collected. Genomic DNA was obtained from whole-blood extraction. Multiplex PCR amplification using GSTM1, GSTT1, and β -Globin gene primers was performed.ResultsGSTM1 and GSTT1 null genotypes frequencies were found in 43.5% (47/108) and 13.9% (15/108) of controls, whereas 54.6% (59/108) and 25.9% (28/108) of OSF patients, respectively. OSF patients had a greater frequency rate of GSTM1 and GSTT1 null genotypes than controls [OR 1.56, 95% CI 0.91-2.67 (p=0.13)] and [OR 2.17, 95% CI 1.08-4.34 (p=0.04)], respectively. The GSTT1 genotype was found statistically significant with OSF (p=0.05), and risk was also determined. The cumulative effect of null genotypes of GSTM1/GSTT1 did not show any association with the controls and in OSF patients. Proportions of active and null alleles of the patient group were; 86.1%/13.9%; and in control, it was 92.6%/7.4% (OR = 2.01; CI: 0.82-4.97; p=0.18), respectively.ConclusionThe study determined a statistically significant association of GSTT1 gene polymorphism with OSF.Key WordsOral submucous fibrosis, GSTM1, GSTT1, Gene polymorphisms, Genetic risk.

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