• Adem Keskin and Recai Aci.
• Department of Medicine Biochemistry, Aydin Adnan Menderes University Institute of Health Sciences, Aydin, Turkiye.
• J Coll Physicians Surg Pak. 2024 Mar 1; 34 (3): 360363360-363.

ObjectiveTo investigate the ability of the procalcitonin to albumin ratio to predict mortality in patients with sepsis.Study DesignObservational study.Place And Duration Of StudyDepartment of Intensive care, Samsun Training and Research Hospital, Samsun, Turkiye, from September to December 2022.MethodologyPatients diagnosed with sepsis admitted to the intensive care unit were included in the study. They were divided into two groups based on their prognosis (expiry/survival). The procalcitonin, albumin, procalcitonin to albumin ratio, C-reactive protein (CRP), lactate, neutrophil, lymphocyte, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels of sepsis patients admitted to the intensive care unit were evaluated. A comparison was made between those who survived and those who expired.ResultsThe procalcitonin, AST levels, and procalcitonin to albumin ratio of the sepsis patients who expired were higher than those of the sepsis patients who survived. Albumin and lymphocyte levels of patients who expired were lower than those in the patients who survived. In the ROC analysis, the sensitivity of the procalcitonin to albumin ratio was 79.20%, and the specificity was 81.80%. The procalcitonin to albumin ratio was positively related with procalcitonin, C-reactive protein, and aspartate aminotransferase levels, and negatively related with albumin and lymphocyte levels.ConclusionA procalcitonin to albumin ratio of 0.185 and above was found to be risky in terms of mortality in sepsis patients.Key WordsProcalcitonin to albumin ratio, Procalcitonin, Albumin, Sepsis.

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