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- Nripen Saikia, Rupjyoti Talukdar, Subhasish Mazumder, Sudeep Khanna, and Rakesh Tandon.
- Department of Gastroenterology, Pushpawati Singhania Research Institute, New Delhi, India. saikia.n@gmail.com
- Postgrad Med J. 2007 Jan 1; 83 (975): 323932-9.
AbstractChronic hepatitis B (CHB) is one of the leading causes of morbidity and mortality worldwide. Although various drugs are available for the treatment of CHB, emergence of the hepatitis B e antigen (HBeAg)-negative mutant variant, specifically in Asia, the Middle East and southern Europe, is creating a new challenge as this variant is less responsive to available treatments. HBeAg-negative CHB rapidly progresses to cirrhosis and its related complications. This review discusses the available literature on the approved and under-trial treatment options and their respective efficacies for HBeAg-negative CHB.
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