• Xu Deng, Chun-Yuan Yang, Zong-Long Zhu, Wei Tian, Jian-Xing Tian, Ming Xia, and Wei Pan.
• Department of Hepatobiliary and Pancreatic Surgery, the People's Hospital of Lezhi, Lezhi, China.
• Medicine (Baltimore). 2024 Mar 15; 103 (11): e37443e37443.

RationaleNegative pressure pulmonary edema (NPPE) is an acute onset of non-cardiogenic interstitial pulmonary edema, commonly seen among surgical patients after extubation from general aneasthesia. It is mainly caused by rapid inspiration with acute upper airway obstruction resulting in significant negative thoracic pressure.Patient ConcernsA 24-year-old female patient who underwent laparoscopic cholecystectomy under general anesthesia and developed NPPE postoperatively.DiagnosesHer main clinical manifestation was coughing up pink foamy sputum; postoperative CT showed increased texture in both lungs and bilateral ground glass opacities.InterventionsDiuretics and steroids were used, and symptomatic supportive treatments such as oxygen were given.OutcomesAfter treatment, on the fourth post-operative day, her symptoms were relieved and her vital signs were stable enough for her to be discharged.LessonsAlthough this is a rare and severe complication, the prognosis of NPPE is good when it is managed with proper diagnosis and treatment.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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